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Furthermore, Reynolds and colleagues found that CSE enhanced the activation of Ras and NFB, and that downregulation of the receptor for advanced glycation end-product (RAGE) resulted in the reduced activation of NFB in alveolar epithelial cells [145]

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Similar studies for menthol IQOS in Japan and the US showed 5094% reductions in biomarkers of exposure to HPHCs 81,82

In May 2023, the county government had already unanimously adopted a resolution recognising that tobacco waste poses a threat to health and the environment and had set up an ad hoc committee to study the issue

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