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When asked by Insider about potential FDA action against other e-cigarette brands, the FDA said it was prioritizing application reviews from "manufacturers with the greatest market share at the time because decisions on those applications were expected to have the greatest impact on public health." "As a result, the FDA allocated significant resources to review applications from the five companies whose brands represented over 95% of the e-cigarette market at that time: Fontem (blu), JUUL, Logic, NJOY, and R.J

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Concordant observations were found in human lung cancer, where NSCLC patients with p53 truncating mutations had shorter OS with immunotherapy compared to patients with WT p53 expressing tumours [196]