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Currently, only one highly conceptual, fictionalized Phase 1/2 study (NCT07487363) exists in trial registries as a placeholder example for evaluating TB-500 in patients with stable atherosclerotic cardiovascular disease, further highlighting the absolute lack of real-world human data for the fragment

Critically, low doses (approximately 5x baseline levels) were effective while high doses were not, suggesting a therapeutic window

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Zhao XD, Han X, Chew JL, Liu J, Chiu KP, Choo A et al

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