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Notably, GHK-Cu levels decline with age : young adults may have around 200 ng/mL in plasma, but levels fall by more than half by age 60

This could include changes in footwear, incorporating foot exercises, and avoiding certain high-impact activities

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Moreover, a recent cohort study of people newly diagnosed with T2D and 10 years of survival data found that an HbA1c 6.5% (48 mmol/mol) for the 1st year after diagnosis was associated with worse outcomes (micro- and macrovascular complications), suggesting also that an early and intensive treatment for people newly diagnosed with T2D may reduce the long-term risk for diabetes complications and mortality [94]

Potential link between antidepressant-like effects of ketamine and promotion of adult neurogenesis in the ventral hippocampus of mice