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The effect of nicotine on weight loss in mice on a HFD was completely blocked by mecamylamine, a nonselective nAChR antagonist, but was only partially blocked by the 42 nAChR partial agonist/antagonist, varenicline, a drug known as Chantix that is currently used in the clinic for smoking cessation [78]

[1] It was however hit by the Great Depression in 1929 and then seized by the Nazis as Jewish property in 1939

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