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DA-sensitive tumors ( More controversial is the association of SS resistance with the reduction of SSTRs expression, since data from literature suggest on the one hand that some GH-secreting tumors are resistant to therapy despite high SSTR2 expression, and on the other hand that the in vivo GH suppression and tumor shrinkage induced by SS analogs correlates with SSTR2 mRNA and protein levels ( Anyway, the molecular events responsible for reduced DRD2 and SSTRs expression are still largely unknown

Safety concerns for cytokines and growth factors are species-specificity, interaction with host endogenous cascade, and tumor-promoting potential