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Preclinical Studies Early preclinical studies in rodent obesity models demonstrated that AOD9604 administration reduced body weight and fat mass without affecting food intake, indicating a direct metabolic effect rather than an appetite-suppressing mechanism

Thus, in these cells, Cys 2 starvation or system x c inhibitor (such as erastin) cannot induce oxidative stress and cell death 26

It also appears to upregulate VEGF and promote angiogenesis at wound sites, accelerating granulation tissue formation 9

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9 studies were excluded as they did not include a healthy control group