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The GSK3 hypothesis of Alzheimers disease: GSK3 and Alzheimers disease

A possible mechanism to understand how Pycnogenol contributes to lower glucose blood levels could be that sugar absorption was slowed down in patients supplemented with Pycnogenol by inhibition of -glucosidase, the enzyme that disassembles starch ( In 21 men with moderate erectile dysfunction, supplementation with 120 mg Pycnogenol per day over a period of three months significantly decreased total cholesterol from 5.41 to 4.98 mmol/L and LDL-cholesterol from 3.44 to 2.78 mmol/L ( supplementation increased the antioxidant activity of plasma determined by the FRAP (ferric reducing ability of plasma) method significantly by 15%

doi: 10.21203/rs.3.rs-3185871/v1

The data suggest that the pyruvate/lactate, as a measure of the cytoplasmic [NAD + ]/[NADH], likely becomes more reduced with fasting in many mouse and human brain regions

Atvb 39 (6), 10451054