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These previous studies [12,13,14,15,16,17] had several limitations such as the inclusion of relatively small number of cases, especially for rare type of congenital anomalies (i.e., being underpowered to detect small or moderate risk effect), the use of case-control design (i.e., being more prone to selection bias), or insufficient adjustment for potential confounders (i.e., being more prone to confounding bias)

[105] In October 2006, it was announced that Tony Iommi, Ronnie James Dio, Bill Ward, and Geezer Butler would be touring together again, though not as Black Sabbath but under the moniker "Heaven & Hell", the title of Dio's first Black Sabbath album

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