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Chronic exposure of mice to e-cigarette aerosol containing PG:VG with or without vanilla flavor led to an increased presence of DCs in the lungs as compared to air controls(38), which potentially could be due to the vanilla flavorant or PG:VG vehicles, as this was the only study finding increased numbers of DCs in the lungs of e-cigarette exposed mice(28, 38)

In a statement linked to the FDA's advanced notice of proposed rulemaking, Commissioner Scott Gottlieb asks "What unintended consequencessuch as the potential for illicit trade or for addicted smokers to compensate for lower nicotine by smoking moremight occur as a result?" I'm glad he asked

Scanning Solutions for the EU Tobacco Products Directive Surviving the EU Tobacco Products Directive The EU Tobacco Products Directive has completely transformed the tobacco supply chain