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Even more amazingly, VLN, by then a registered trademark, became the first combustible cigarette product in the US to ever having successfully gone through both the pre-market tobacco product application [PMTA] and the modified risk tobacco product [MRTP] processes

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Additionally, while we observed a positive relationship between elevated serum cotinine levels and total testosterone levels, it remains unclear whether this association is reversible and if testosterone levels decrease upon smoking cessation

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