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Elevated COX-2 promotes inflammation and prostaglandin synthesis, while VEGF stimulates angiogenesis, both facilitating tumor growth and metastasis
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Additionally, the following may produce brain fog: Oxygenation problems due to lung or cardiac issues Inflammation in multiple systems Medication side effects Sleep disturbance Stress, anxiety, and social isolation Under investigation: role of the hypothalamus filtering waste in the brain (microglia/CSF) Other Disease Processes Fibromyalgia Myalgic encephalomyelitis Lupus Traumatic Brain Injury (TBI) Orthostatic intolerance and other cerebral blood flow issues Iatrogenic causes (i.e., treatments creating symptoms: chemotherapy, medication side effects, restricted diets for weight loss) NOTE: please discuss any concerns with your doctor and do not discontinue recommended treatments although some treatments may cause adverse side effects, they are life saving and may have the potential to improve cognitive functioning (for example, when an obese person loses weight) As you can see, many conditions and factors can cause or contribute to brain fog
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