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Assuming that a conventional cigarette contains 0.1721.702 mg of nicotine [51], the daily nicotine dose administered to these animals corresponds to 40400 cigarettes for a 70 kg-adult, which is a dose of an extremely heavy smoker

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However, mishaps have happened.

47 CS exposure has also been shown to increase TNF, which is central to acute smoke-induced inflammation and resulting connective tissue breakdown, 49 a precursor of emphysema development