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Cigarette smoke induced lung barrier dysfunction, EMT, and tissue remodeling: a possible link between COPD and lung cancer

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32 found that the mean number of cigarettes smoked per day was greatest in 1986 and declined by 4 to 5 cigarettes per day between 1986 and the period 2002 to 2003

If that changes when those are the only flavors left, as some public health advocates fear, that stance may need to be reevaluated