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In some cases, e-cigarettes stimulate the production of ROS in alveolar macrophages, causing lung epithelial damage and neutrophil influx at injury sites, resulting in aggravated inflammation, mucus production, and destruction of alveolar cells, leading to airway obstruction [53]

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Different TSNAs are formed from the reaction of alkaloids with nitrite 8 , and levels of available nitrite are influenced by nitrite-reducing bacteria that are known to be part of a variety of bacteria, or microbiota, associated with tobacco products 9