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Seven of those states (Alaska, California, Colorado, Massachusetts, Nevada, Oregon, and Washington State) have retail businesses that are selling cannabis and collecting state and local taxes and two more states, Maine and Michigan, are in the process of regulating and licensing their legal markets

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Previous studies have investigated both puffing regimes concurrently using different study designs (e.g., a few minutes of fixed use, followed by up to an hour of ad libitum use) 11,27,28

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