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37 , 38 It has been suggested that nicotine pouches may introduce the 'gateway effect', providing a steppingstone to cigarette smoking due to the combination of addictive nicotine, pleasant flavours and attractive packaging

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The wear on the back of the neck is the only sign of age and usage, but all in all very clean

Nicotine does not produce the kind of euphoria or impairment that many other drugs like opioids and marijuana do, Volkow added