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[2] It aimed to challenge discount brands such as L&M, which cost $3.69, and Pall Mall which cost $3.49

Safety Margin (Dotted Green Lines): The safety margin, marked by dotted green lines, is the area around the cut line where important elements (such as text, logos, or graphics) should be kept clear

The effect of cytokines on barrier integrity has been reviewed previously: pro-inflammatory cytokines can weaken the barrier, whereas anti-inflammatory mediators stabilize barrier properties of the epithelium (87)