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Patient-derived xenograft (PDX) cells that survived after treatment with various anticancer drugs showed lower risk scores (RS), lower KRAS expression levels, lower activation states of the RAS-MAPK signaling pathway, and significantly different expressions of ion channel transport genes, which may be related to drug resistance mechanisms (Kim et al., 2015)

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Therefore, the possibility that depression disorders could be effectively influenced by a primary antiulcer agent with a cyto/organoprotective activity, such as the novel stomach pentadecapeptide bpc 157, was investigated in two rat depression assays

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