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Shampa Chatterjee American Journal of Physiology 2019 In animal models, e-cigarette exposure has been linked to increased levels of inflammatory cytokines like IL-6 and TNF-, as well as neutrophil infiltration and NF-B pathway activation, which are indicative of acute lung inflammation

At that time, the FDA stated it did not possess the ability to extend tobacco product regulations to these synthetic nicotine products

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For example, the 2009 Youth Risk Behavior Surveillance reported that SLT use increased among high school students from 6.7% to 8.9% between 2003 and 2009, with an increase from 11% to 15% among male students ( Additionally, research shows that there was an increase from 13.6% to 15.4% among 18-25 year old non-Hispanic white men [35]