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The pharmacology of these orphan receptors displays significant overlap with CB1 and CB2, particularly for GPR18 and GPR55, although our understanding of these receptors within the respiratory system remains limited

Interestingly, the existence of harmful concentrations of diethylene glycol, a known cytotoxic agent, in e-liquid aerosols is contentious with some studies detecting its presence [4, 68, 70,71,72], and others finding low subtoxic concentrations [73, 74]