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Although NOTCH signaling drives secretory cell fate in the differentiating airway epithelium 21,22 , and the transcription factor (TF), SPDEF 23,24 , specifically drives inflammation-induced mucus metaplasia, converting club cells into mucus cells in mice 25 , little else is known regarding regulation of human secretory cell development

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It is the phylogenetically more recent cortical regions of the CNS that demonstrate the ongoing and prolonged development through childhood and into adolescence (28)