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Immune Protection Declines Over Time Over time, the antibodies created in response to that years vaccine begin to lose their effectiveness, though some individuals who received annual flu shots over many years maintain reserve immunity capable of preventing or softening the blow of a new infection even if challenged with a novel strain

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Over time, these conditions can lead to more serious diseases like coronary artery disease, heart attack, stroke, heart failure, peripheral artery disease, and abdominal aortic aneurysm