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Possible Side Effects Mild side effects of Vitamin B12 may include: ( 12 ) Mild pain, itching, or swelling at the injection site Temporary nausea or headache Mild diarrhea Hot flashes Vomiting These side effects do not affect all patients and are generally temporary and mild While rare, more serious side effects of Vitamin B12 injections can include ( 12 ): Irregular heartbeat Heart palpitations Hives or skin rash If you notice any severe reactions to a Vitamin B12 shot, contact a medical professional immediately

Taking certain medicines can interfere with how your body absorbs vitamin B12

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B12 is one of the most common vitamin deficiencies

However, there is no robust evidence that B12 injections provide benefits to individuals with normal B12 levels