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Fragmented oxidized mtDNA enters the cytosol where it activates NLRP3 inflammasome and generates the production of IL-1, IL-18, and cyclic GMP-AMP synthase-STING, inducing type I interferons and interferon-stimulated genes (Orekhov et al., 2023)

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Low-level ionizing radiation may induce irreparable DNA damage (leading to replicational and transcriptional errors needed for neoplasia or may trigger viral interactions) leading to pre-mature aging and cancer

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