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However, portal insulin delivery is also an essential co-player in the regulation of the GH/IGF-I axis by affecting and regulating hepatic GH receptor synthesis, and subsequently altering hepatic GH sensitivity and IGF-I generation

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Pharmacodynamic (PD) biomarkers are defined as the biological response to a drug treatment (Sawyers 2008) and either are treatment specific or may represent endogenous phenotype changes in a subject due to a drug treatment (Beger and Colatsky 2011)