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The carbon monoxide and nicotine gas in tobacco smoke reduces the ability of blood to carry oxygen to tissues effectively
Water-soluble tobacco components can cause mitochondrial outer membrane permeabilization (MOMP)
Mol Cell Biochem 253(1):159165 El-Zein RA, Young RP, Hopkins RJ, Etzel CJ (2012) Genetic predisposition to chronic obstructive pulmonary disease and/or lung cancer: important considerations when evaluating risk
It is indisputable that e-cigarettes, which do not contain tobacco and do not burn anything, are far less hazardous than the real thing, and it's public health malpractice to suggest otherwise
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