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In our study, the upregulated metabolites of 1-methylxanthine, 7-methylxanthine, and theobromine, as well as downregulated caffeine, in the HN versus LN groups, resulted in enriching caffeine metabolism, suggesting that caffeine metabolism exhibited marked changes in the LN group

[125] Previously, opium had only been ingested via consumption, and then only for its medicinal properties (opium was an anaesthetic)

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