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DECLARATIONS Authors contributions Developed the model, ran simulations and analyses, interpreted the findings, and contributed to the writing and editing of the manuscript: Cruikshank A, Reed MC, Nijhout HF Availability of data and materials Computer models and codes used in this paper can be obtained from the authors by request

Recommended Reagents for Sample Preparation: 10 EDTA Anticoagulant, PMSF Protease Inhibitor, 0.25% Trypsin Solution