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It is of the utmost importance to investigate further the possible long-term effects of daily e-cigarette use through studies that are funded independently of the e-cigarette industry. Dr Lundbck and his colleagues are continuing to investigate the effects of e-cigarettes on blood vessel and lung functions in humans, as well as carrying out studies in the lab of the effect of e-cigarette vapour and liquid on cell cultures.

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In rare cases, exposure to certain chemicals in vaping liquids, such as diacetyl, has been linked to popcorn lung (bronchiolitis obliterans), a condition that damages the small airways in the lungs

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But unlike patches or gums, e-smokes operate in a legal gray area