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It revealed that "non-smokers demonstrated a significantly lower degree of transepidermal water loss when compared with both active and passive smokers." If the skin barrier is damaged irritants such as cigarette smoke and other toxins penetrate directly into the epidermis and dermis the deepest layers of the skin causing many problems

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Nicotine and other chemicals in tobacco constrict blood vessels, raise blood pressure, and promote the formation of blood clots, all of which contribute to cardiovascular complications