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The men had to chew for 20 minutes on one piece of gum, thus releasing about two-thirds of the nicotine

We used locally weighted regression and smoothing because both visual inspection and analysis of residuals using a preliminary linear regression indicated a nonlinear relationship between odds of disease progression and mean or median age reported in each study

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That could (but would not necessarily) include prohibiting the most dangerous among them (presumably those delivering the highest levels of nitrosamines) while actually encouraging smokers who would not otherwise quit smoking to adopt the least dangerous alternative