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Among several key considerations, the agencys evaluation showed that, due to substantially lower amounts of harmful constituents than cigarettes and most smokeless tobacco products, such as moist snuff and snus, the authorized products pose lower risk of cancer and other serious health conditions than such products

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Harlequin's parents Colombian Gold, Thai, and Swiss are all landrace strains, contributing unique, authentic characteristics refined by generations of natural selection

These important parameters of a cMRTP can be assessed through measuring product use satisfaction, craving, nicotine exposure and daily consumption in clinical studies conducted in an ambulatory setting [44]