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These along with telomere damage, as a result of oxidative stress, lead to upregulation of the cell cycle inhibitor p16 INK4 and mammalian target of rapamycin (mTOR)-mediated signalling to trigger premature senescence in COPD airway epithelial cells (145149)

Tobacco giant BAT reports disappointing US cigarette sales but gains vapers British American Tobacco insisted its strategy has not changed since new boss Tadeu Marroco took over last month