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In addition, the IL-31/IL-31RA axis contributes not only to pruritus signaling but also to the immunoregulatory balance by inducing the neurogenic release of CGRP, which negatively regulates Th2 responses

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The immediate effects of tobacco addiction are as follows: Increased blood pressure and heart rate Shortness of breath Persistent coughing Reduced respiratory function Discomfort during daily activities Long-term Health Risks : The long-term smoking is a leading cause of various cancers, including lung, throat, and mouth cancers, as studied by Waldum HL et al

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