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There is also "compelling evidence" that regular cannabis use increases the risk of developing psychotic illnesses, such as schizophrenia, particularly in adolescents, according to Dr Marta Di Forti, from King's College London

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These neuropeptides bind to tachykinin (NK1, NK2, and NK3) and CGRP receptors on effector neurons to promote and modulate early inflammatory responses including vasodilation, extravasation of plasma protein, leukocyte recruitment, mucus hypersecretion, and airway constriction [113]