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In summary, laboratory rats under ideal laboratory conditions will be more resistant to APAP-induced neurodevelopmental injury than humans that have significant problems metabolizing the drug

Hydroxocobalamin is produced naturally by gut bacteria when digesting food

It is diagnosed through skin biopsy showing reduced intraepidermal nerve fiber density (IENFD) or corneal confocal microscopy showing reduced corneal nerve fiber density

Although the initial results with portosystemic shunts may be beneficial, the long-term outcome for patients who require shunts is poor because these patients usually have severe SOS and intervention generally delays, but does not prevent, a fatal outcome