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Chronic inflammation, often driven by persistent infections, autoimmune diseases, or environmental factors, can create a pro-tumorigenic environment [110]

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But that burst is a one-time event -- the growth factors are released over days, and then the stimulus fades until your next session 4-6 weeks later

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Probably the most important proxy of tolerability is patients who have to withdraw from therapy due to the gastrointestinal side effects when it gets that severe, and we had none here, Frias said