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Live cell imaging of mitochondrial redox state in mammalian cells and yeast

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Cancer cells rewire lipid metabolism on two fronts: they boost de novo fatty-acid synthesis by up-regulating ACLY, ACC, and especially fatty-acid synthase (FASN), so that even in lipid-rich environments endogenous palmitate production can furnish membranes, signalling lipids, and an NADPH sink that buffers oxidative stress [110, 111]

In this way, each LTCH's relative charge value is adjusted by its case-mix to an average that reflects the complexity of the applicable LTCH cases it treats relative to the complexity of the applicable LTCH cases treated by all other LTCHs (the average LTCH PPS case-mix of all applicable LTCH cases across all LTCHs)