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Child-resistant packaging for liquid nicotine refills As of 2016, the federal government requires liquid nicotine to be sold in childproof packaging

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Various neurotransmitters, including glutamate, GABA, serotonin, acetylcholine, norepinephrine, and endorphins, also modulate nicotines diverse effects [17,18]

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Although it was claimed that the purpose of use was to help quit smoking, its effect on this issue could not be proven, its production was taken over by the tobacco industry over time, and its advertisements were made widespread by making many changes in its content