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With the in-depth study, it has been found that they can specifically act on ion channels (Na + , K + , Ca 2+ , Cl ) on the membrane to play antibacterial, anticancer, anti-inflammatory, and immunomodulatory roles (Vega et al., 2010)

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However, despite the biochemical plausibility, optimal dose, recommended timing of administration, and appropriate choice of outcome measures, no significant changes were observed in oxidative stress biomarkers or erythrocyte glutathione concentrations following 4 weeks of oral GSH supplementation in healthy adults

Remission of Graves disease during anti-thyroid drug therapy

However, low to moderate levels of ROS can promote cancer cell survival and metastasis pathways through DNA damage-induced genomic instability, epigenetic regulation, metabolic reprogramming, and generation of pro-inflammatory and pro-tumorigenic microenvironment in a context-dependent manner [8, 12, 13, 26]