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AMPK1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation

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Final concentrations of DM, D90A and K26A were 510 nM, 512.5 nM and 50100 nM, respectively

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The overproduction of lactate would thus be secreted into the circulation through MCT4 and preferentially bind to GPR81 on endothelial cells, to reduce endothelial VE-Cadherin expression and increase vascular permeability through different signaling

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