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31 As early as 1992, a RCT (N=155) randomized cocaine users to fluoxetine (20 mg, 40 mg, or 60 mg/d) or placebo, finding that fluoxetine appeared to worsen treatment success possibly dose-dependently

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Similarly, we observed an increase in the expression of the ABA biosynthetic gene, NCED1 , in both tobacco varieties, under PEG-induced water stress, suggesting that ABA-mediated stomatal closure is associated with an increase in drought tolerance

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He also notes that new generation products continue, in many cases, to benefit from a tax advantage compared to cigarettes, which may encourage their use by young people or non-smokers, as well as dual use rather than complete cessation