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Diet and exercise remain the foundation every other intervention is built on, and they meaningfully improve obesity-related conditions such as hypertension and type 2 diabetes

These reviews focused more on animal experiments and did not sort out the heterogeneous results and related mechanisms produced in clinical research, so as to provide more high-quality evidence and systematic summary

Ahren, B

Hypoglycaemia: Whilst these agents are not expected to cause low blood sugar on their own, people with diabetes who are also taking insulin or sulfonylureas may be at increased risk of hypoglycaemia

Anaphylactic shock and death have been reported after parenteral Vitamin B12 administration