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For instance, increased exhausted PD1+ natural killer (NK) cells have been reported in advanced stages of the disease, indicating a role for immune checkpoint dysregulation in disease progression and potential as a diagnostic target

These stressors can compromise immune function, impair growth rates and alter behaviour, leading to increased disease susceptibility and reduced performance [19, 83]

Preclinical investigations of the efficacy of the glutaminase inhibitor CB-839 alone and in combinations in chronic lymphocytic leukemia

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