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Consistent with the predicted interaction between GLR3.3 ATD and GSH (Supplementary Fig

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Specifically, IRE enhances systemic antitumor T-cell activation while downregulating immunosuppressive mechanisms in localized disease, promoting tumor antigen-specific expansion of tissue-resident memory CD8 + T cells (TRM) for durable immune surveillance ( In vitro and magnetic resonance imaging (MRI) assessments further validate IREs ability to achieve sustained tumor regression ( 3.4 Melanoma PEFs represent a highly suitable therapeutic approach for melanoma, primarily because these tumors are typically located in superficial layers, allowing for direct percutaneous minimally invasive intervention that yields clinically significant outcomes

Sapam, R., Agrawal, S., Phil, M