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Consumer panel data from other studies indicates adult tobacco users find nicotine pouches moderately to extremely appealing, and are by far the largest group of regular users, with harm reduction and health reasons cited as the main reason for use.[efn_note]Plurphanswat N

Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines

A 5-fold cross-validation scheme with up to 15 repetitions was used, and the model performance was assessed by Pearsons correlation coefficient and the Mean Absolute Error (MAE) between predicted and real chronological ages in the test sets

Only four studies adjusted smoking as confounding variable while three considered salt intake as a confounder

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