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In terms of gender distribution, the vast majority of the studies reviewed recruited more female participants (64.31%) than male participants (35.69%)

Acknowledgements The authors gratefully acknowledge Fadwa Shokry Elbaz for her expertise in designing and illustrating the figures presented in this manuscript

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CIGARETTES SMOKED PER YEAR PER SMOKER June 6, 1960 The American Heart Association announces coronary death rates are 50 to 150 percent higher among heavy smokers than among nonsmokers