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Video by Simon Wharf / University of Bath.

Early findings suggest that using ENDS poses some cardiovascular risks (e.g., higher blood pressure and hardened arteries

Brain Imaging Behav , 10.1007/s11682-016-9511-z (2016)

Besides the confirmatory evidence (a person actually smoking a cigarette in public view), nicotine-stained fingers and teeth, the characteristic smell of smoke impregnated clothing and household items, the chronic "smokers cough," the gravelly voice, and often the visible pack of cigarettes and lighter in a person's pocket or purse are signs and symptoms that a person smokes

Answer: THCa does not strongly bind to CB1 receptors in the brain due to its carboxyl group