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Nicotine is like a master key that fits perfectly into specific receptors (nAChRs) that are directly wired to the brain's "reward" pathway

Strengths and Limitations The strengths of this meta-analysis include the large pooled sample size (24,000 participants, from multinational countries like USA, UK, South Korea, Canada, and Colombia), the integration of multiple biomarker types (nicotine metabolites, TSNAs, and cytokines), and the application of GRADE methodology to assess the certainty of evidence

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